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Hollow Fiber Membrane Filters

Hollow Fiber Membrane Filters

Hollow Fiber Membrane Filters

Hollow fiber membranes offer ultra-high surface area with low pressure drop for UPW, biopharma and high-flow applications.

Hollow fiber membrane filters use PVDF or Polysulfone hollow fiber media — each fiber a 0.5–2 mm microtubular membrane — bundled by the thousands into a single cartridge to deliver 5–10 m² of effective filtration area, 2–3× that of an equivalently-sized pleated cartridge. Flow can be configured Inside-Out or Outside-In, with both dead-end and tangential (cross-flow / TFF) operation modes supported.

The core advantages of hollow fiber filters are maximized surface area and ultra-low pressure drop, making them ideal for high-flow, high-turbidity applications requiring frequent backwash. Air-scour-plus-backwash protocols restore flux and extend service life far beyond static depth filters. Hydrophilic treatment ensures instant wetting and prevents air lock.

Typical applications: UPW recirculation filtration, mAb/vaccine TFF tangential-flow purification, biotech cell harvesting, municipal UF water treatment, food & beverage clarification, wastewater reuse pretreatment, and RO membrane protection in seawater desalination.

Frequently Asked Questions

How to choose between hollow fiber and pleated cartridge filters?
Hollow fiber offers large surface area (5–10 m²), low pressure drop, and backwashability — ideal for high-flow, high-turbidity applications requiring frequent recovery. Pleated cartridges suit low-fouling fluids requiring full integrity and seal validation, such as sterile filtration. Use hollow fiber for pharmaceutical TFF.
Can hollow fiber be used for tangential flow (TFF / Cross-Flow)?
Yes — it is the mainstream TFF choice. Maintaining cross-flow velocity > 3× permeate flux effectively controls concentration polarization. Used for mAb, vaccine, and cell harvesting in biotech. MWCO range: 1 kDa to 750 kDa.
How are hollow fiber membranes cleaned and stored?
After use, immediately backwash with RO water, then soak with 0.1N NaOH for 30 min to remove organics, followed by 0.1% NaClO sanitization. For long-term storage, immerse in 0.1% NaClO or 20% glycerol — never dry, as this causes irreversible flux loss.

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