Sterile Positive Charge Nylon66 Capsule Filter

Filter media / membrane

Positively charged modified Nylon 66 membrane. On top of sieving by pore size, the charged surface electrostatically adsorbs negatively charged contaminants — endotoxin, colloids and ultrafine particles smaller than the pores are retained too, which a neutral membrane of the same rating cannot do

Support & drainage layers

Polypropylene support and drainage layers

Body material

One-piece polypropylene shell and end caps, thermally welded throughout with no adhesives; no metal parts in the wetted path

Seals / O-rings

The body is thermally welded and has no main O-ring; port gaskets in silicone or EPDM, with FKM available for aggressive fluids

Micron rating

0.2, 0.45, 0.65, 1.2 µm; 0.2 µm is the sterilising grade. The electrostatic contribution is not counted in the stated rating, which remains a sieving rating

Effective filtration area

About 0.7 m² per 10" media section; small capsules run about 0.02–0.2 m². Adsorptive capacity scales with area, so size with margin when the duty is depyrogenation

Inlet / outlet connections

Inlet/outlet 1/4"–1-1/2" with hose barb, sanitary tri-clamp, threaded and quick-connect options; the connections are moulded into the same polypropylene body

Hold-up volume

Small (≈0.02 m²) ≈30 mL; mid (≈0.1 m²) ≈90 mL; 10" class (≈0.7 m²) ≈250 mL. Most of the hold-up is recoverable by blowing down through the open drain

Vent & drain

One polypropylene vent valve on top and one drain valve underneath, both hand-operated; the vent can take a hydrophobic membrane cap to keep the sterile boundary intact

Max operating temperature

Continuous service to 60 °C; withstands 121 °C saturated steam for sterilisation cycles

Max forward differential pressure

Forward 4.0 bar (58 psi) @ 25 °C; 1.0 bar (15 psi) @ 60 °C; reverse 2.0 bar (29 psi) @ 25 °C

Recommended change-out ΔP

A single-use capsule cannot be backwashed or regenerated. Adsorptive capacity is exhausted before ΔP rises noticeably, so on depyrogenation duty set the change-out on cumulative throughput rather than on ΔP

Sterilisation

Autoclave at 121 °C for 30 min, up to 3 cumulative cycles recommended; steam-in-place, EtO and gamma sterilisation are also available

Wetting & flushing

Strongly hydrophilic and wets out with aqueous feeds directly, no alcohol pre-wet. Adsorption depends on the feed ionic strength and pH — a high-salt feed screens the charge and weakens capture, so confirm with the real feed before adoption

Extractables & cleanliness

Flushed with purified water to conductivity and TOC limits before shipment; extractables, endotoxin (< 0.25 EU/mL) and TOC batch data available on request

Integrity test

100% integrity tested before shipment; a water-wet 0.2 µm membrane typically bubbles at ≥ 3.4 bar (50 psi). Validate depyrogenation separately with an endotoxin challenge — a bubble point says nothing about adsorptive capacity

Packaging

Individually double-bagged, assembled and sealed in a cleanroom; gamma pre-sterilised units available

Regulatory & validation

Wetted materials meet USP Class VI biological reactivity and 21 CFR 177 food-contact requirements; material certificates and batch test reports can be supplied with the shipment

Note: actual compatibility and service life depend on chemical concentration, temperature, flow, differential pressure, upstream contamination load and housing design. Validate under your real process conditions.

Values shown are typical for this product class; actual supply specification follows the quotation and sample datasheet.